For research use only. Not for human consumption.
PT-141 (Bremelanotide) is a synthetic cyclic peptide that activates MC3R and MC4R melanocortin receptors in the CNS, stimulating sexual arousal and libido, and is used in research on sexual dysfunction and melanocortin signaling.
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7 in stock
PT-141 is a synthetic cyclic heptapeptide and a melanocortin receptor agonist, primarily targeting MC3R and MC4R in the central nervous system. Unlike other melanocortin analogs like MT-1 or MT-2, PT-141’s main function is modulation of sexual behavior and arousal, rather than skin pigmentation. It works by activating hypothalamic melanocortin pathways, leading to increased libido and sexual responsiveness. Chemically modified for stability, water solubility, and resistance to enzymatic degradation, PT-141 is suitable for preclinical research on sexual dysfunction, CNS melanocortin signaling, and behavioral studies.
Peptide Type: Cyclic heptapeptide
Mechanism of Action: Activates MC3R and MC4R receptors in the CNS
Primary Effect: Enhances sexual arousal and libido
Water-Soluble: Suitable for in vitro and preclinical studies
Stability: Resistant to enzymatic degradation for research applications
Investigating sexual arousal mechanisms and libido regulation
Studying MC3R and MC4R receptor pharmacology
Research on hypoactive sexual desire disorder (HSDD) and erectile dysfunction models
Exploring CNS melanocortin-mediated behavioral pathways
PT-141 is a stable cyclic peptide that selectively targets central melanocortin receptors to modulate sexual behavior and libido. Its CNS activity, receptor specificity, and chemical stability make it a valuable tool for preclinical research in sexual physiology and melanocortin signaling.
Type: Synthetic cyclic peptide (heptapeptide)
Amino Acid Length: 7 residues
Molecular Weight: ~1025 Da
Structure: Cyclic peptide derived from α-MSH analogs, chemically modified for stability and receptor specificity
Receptor Targets: Primarily MC3R and MC4R in the CNS; minor affinity for other melanocortin receptors
Sexual Arousal Activation: Stimulates MC3R/MC4R signaling in the hypothalamus
Mechanism: Activates cAMP-dependent melanocortin pathways, influencing sexual behavior
Enzymatic Stability: Resistant to proteases due to cyclic structure
Secondary Effects: Can modestly influence appetite and energy metabolism through melanocortin pathways
Sexual Function: Increases libido, sexual arousal, and erectile response in preclinical models
CNS Modulation: Works through central melanocortin pathways rather than peripheral melanogenesis
Behavioral Impact: Alters sexual motivation and mating behavior in animal studies
Water-Soluble: Suitable for in vitro and preclinical studies
Cyclic Structure: Enhances stability, bioavailability, and receptor affinity
Resistance to Degradation: Longer half-life compared to linear α-MSH analogs
PT-141 is a cyclic melanocortin receptor agonist with a stable 7-amino-acid structure that selectively targets MC3R and MC4R in the CNS. Its biochemical characteristics—cyclic structure, water solubility, protease resistance, and receptor specificity—make it ideal for research on sexual function, melanocortin signaling, and CNS-mediated behavioral studies.
Investigating mechanisms of sexual arousal and desire
Studying erectile function and libido modulation in preclinical models
Researching hypoactive sexual desire disorder (HSDD) and sexual dysfunction therapies
Studying MC3R and MC4R receptor signaling in the central nervous system
Exploring structure-activity relationships of melanocortin receptor agonists
Evaluating CNS receptor-specific effects versus peripheral melanocortin activity
Examining CNS-mediated sexual motivation and mating behavior
Investigating neuroendocrine pathways regulating sexual response
Studying melanocortin-driven behavioral and physiological effects
Exploring minor effects on appetite, energy balance, and metabolic regulation
Studying potential central nervous system effects of melanocortin receptor activation
PT-141 is primarily used in research to study sexual function, libido, and CNS melanocortin receptor signaling. Its cyclic peptide structure and receptor specificity make it a valuable tool for preclinical studies on sexual behavior, erectile function, and melanocortin-mediated neuroendocrine pathways.
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Temperature: Store refrigerated at 2–8 °C (36–46 °F) for short-term stability
Long-Term Storage: Freeze at −20 °C or lower to maintain activity
Light Protection: Keep protected from direct light
Moisture Protection: Store in sealed, dry vials
Shelf Life: Typically 12–24 months when stored properly
Diluent: Sterile water or bacteriostatic water
Temperature: Store refrigerated at 2–8 °C
Use Period: Recommended within 7–14 days
Handling: Gently swirl to dissolve; avoid vigorous shaking
Do NOT freeze after reconstitution
Inspect solution before use: should be clear, colorless, and free of particulates
Discard if cloudy, discolored, or precipitated
Use sterile techniques during reconstitution and experimental handling
Protect from heat, light, and mechanical agitation to maintain peptide integrity
PT-141 is most stable as a lyophilized powder stored refrigerated or frozen. Once reconstituted, it should be kept cold, protected from light, and used promptly to preserve biological activity for research on sexual function, CNS melanocortin signaling, and neuroendocrine studies.
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