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Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.

For research use only. Not for human consumption.

GHK-Cu (50mg)

GHK-Cu is a naturally occurring tripeptide–copper complex (Gly-His-Lys + Cu²⁺) known for its regenerative, tissue-repair, and anti-aging properties, including stimulation of collagen and elastin synthesis, wound healing, and skin remodeling. It is primarily used in research and experimental studies.

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$95.00

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8 in stock

Overview

GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper Complex) is a naturally occurring tripeptide that binds copper ions, forming a biologically active complex involved in tissue repair, regeneration, and skin remodeling. It was first identified in human plasma and is found in high concentrations in young, healthy tissue, with levels declining with age.

Key Features

  • Peptide Sequence: Gly-His-Lys

  • Copper Complex: Cu²⁺ binding enhances stability and bioactivity

  • Functions: Promotes collagen and elastin synthesis, wound healing, hair growth, antioxidant activity, and gene modulation

  • Applications: Anti-aging research, skin regeneration studies, wound healing models, and hair follicle stimulation

Mechanism of Action

  • Regulates gene expression related to tissue repair and extracellular matrix production

  • Enhances cell proliferation and angiogenesis

  • Reduces inflammation and oxidative stress in damaged tissues


Summary

GHK-Cu is a small, naturally occurring tripeptide–copper complex with potent regenerative, anti-aging, and tissue-repair properties, making it a key focus in cosmetic, dermatological, and regenerative medicine research.

Biochemical
Characteristics

1️⃣ Peptide Structure

  • Type: Tripeptide

  • Amino Acid Sequence: Glycine–Histidine–Lysine (Gly-His-Lys, GHK)

  • Copper Binding: Forms a complex with Cu²⁺ ions, essential for biological activity

  • Molecular Weight: ~340–345 Da (varies with copper binding)

  • Structure: Linear, small, water-soluble peptide


2️⃣ Physicochemical Properties

  • Solubility: Highly soluble in water

  • Charge: Positively charged at physiological pH due to lysine residue

  • Stability: Copper binding enhances peptide stability and protects against enzymatic degradation

  • pI (Isoelectric Point): Slightly basic due to lysine residue


3️⃣ Functional Biochemistry

  • Tissue Repair: Stimulates collagen, elastin, and glycosaminoglycan synthesis

  • Gene Modulation: Regulates expression of genes involved in cell proliferation, angiogenesis, and extracellular matrix remodeling

  • Anti-Inflammatory & Antioxidant: Reduces oxidative stress and inflammation in tissues

  • Hair Growth: Promotes hair follicle activation and keratinocyte proliferation


4️⃣ Molecular Behavior

  • Small size allows rapid diffusion and tissue penetration

  • Copper complex stabilizes peptide and enhances bioactivity in extracellular matrix and cell signaling pathways

  • Linear and amphipathic structure facilitates interaction with cellular receptors and extracellular matrix proteins


5️⃣ Summary

GHK-Cu is a small, linear tripeptide bound to copper, giving it enhanced stability and potent regenerative activity. Biochemically, it is involved in tissue repair, collagen and elastin synthesis, gene modulation, antioxidant protection, and hair follicle stimulation, making it a widely studied peptide in cosmetic, dermatological, and regenerative medicine research.

Research Applications

1️⃣ Skin Regeneration and Anti-Aging

  • Studied for collagen and elastin synthesis in skin

  • Promotes wound healing and tissue remodeling

  • Reduces wrinkle formation, skin sagging, and age-related damage

  • Investigated in cosmetic and dermatological research


2️⃣ Wound Healing and Tissue Repair

  • Enhances angiogenesis, fibroblast proliferation, and extracellular matrix deposition

  • Used in experimental models of burns, cuts, and ulcers

  • Supports accelerated recovery in tissue injury models


3️⃣ Hair Growth Studies

  • Promotes hair follicle activation and keratinocyte proliferation

  • Studied for androgenic alopecia and hair regeneration in preclinical research


4️⃣ Anti-Inflammatory and Antioxidant Research

  • Modulates oxidative stress pathways

  • Reduces inflammation in damaged tissues

  • Explored in models of chronic tissue damage or aging-related inflammation


5️⃣ Gene Modulation and Regenerative Medicine

  • Influences gene expression related to tissue repair, extracellular matrix, and cell proliferation

  • Used to study peptide-mediated regenerative therapies

  • Explored in preclinical tissue engineering and cellular rejuvenation models


Summary

GHK-Cu is widely used in research to study skin and tissue regeneration, anti-aging mechanisms, hair growth, wound healing, and gene modulation. Its copper-bound tripeptide structure makes it highly effective in promoting collagen synthesis, angiogenesis, and extracellular matrix remodeling, making it a key focus in dermatological and regenerative medicine research.

Chemical Properties

GHK-Cu Chemical Properties

Chemical Name: Glycyl-L-Histidyl-L-Lysine Copper(II) Complex
Common Names: GHK-Cu, Copper Peptide, Copper Tripeptide-1

Molecular Information

  • Molecular Formula: C₁₄H₂₄CuN₆O₄ (reported variants may differ slightly by ionization state)
  • Molecular Weight: ~403.9 Da
  • Peptide Sequence: Gly-His-Lys bound to copper ion (Cu²⁺)

Physical Characteristics

  • Appearance: Blue to blue-violet powder or crystalline solid due to copper complexation
  • Odor: Odorless
  • Solubility: Highly soluble in water; poor solubility in oils
  • pH Stability: Generally more stable in mildly acidic to neutral aqueous environments

Structural Properties

  • Type: Tripeptide-metal chelate
  • Copper Binding: Strong affinity for Cu²⁺ ions via histidine and peptide nitrogen atoms
  • Charge: Depends on pH and formulation state

Stability / Storage

  • Best stored refrigerated (2–8°C)
  • Protect from light and moisture
  • Lyophilized form more stable than liquid solution
  • Reconstituted solutions degrade faster over time

Functional Chemical Traits

  • Acts as a copper delivery peptide
  • Strong antioxidant potential via copper-enzyme support
  • Used in formulations for skin, hair, and tissue research

Cosmetic / Research Relevance

Because of its small molecular size and water solubility, GHK-Cu is frequently used in serums, topical solutions, and regenerative research compounds.

COA /HPLC / MS

3rd Party Testing
Storage

1️⃣ Lyophilized (Powder) Form

  • Temperature: Store refrigerated at 2–8 °C (36–46 °F)

  • Light Protection: Keep protected from direct light

  • Moisture Protection: Store in the original sealed vial

  • Freezing: Can be stored at −20 °C for long-term storage

  • Shelf Life: Typically 12–24 months when properly stored


2️⃣ Reconstituted Solution

  • Diluent: Sterile water or bacteriostatic water

  • Temperature: Refrigerate at 2–8 °C

  • Use Period: Typically recommended within 7–14 days

  • Handling: Gently swirl to mix; do not shake vigorously

  • Do NOT freeze after reconstitution


3️⃣ General Precautions

  • Inspect solution before use: should be clear and colorless

  • Discard if cloudy, discolored, or containing particulates

  • Use sterile technique during reconstitution and handling

  • Protect from heat, light, and mechanical agitation


Summary

GHK-Cu is most stable as a lyophilized powder stored refrigerated or frozen. Once reconstituted, it should be kept cold, protected from light, and used promptly to maintain biological activity for research applications.

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