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Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.
Epithalon (10mg)

For research use only. Not for human consumption.

Epithalon (10mg)

Epithalon (Epithalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) studied for its potential anti-aging and longevity-promoting effects, primarily through telomerase activation, cellular senescence modulation, and pineal gland regulation. It is investigational and used in research settings.

Price:

$55.00

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5 in stock

Peptide Compounds
Overview

Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the naturally occurring pineal peptide epithalamin. It is primarily studied for its potential anti-aging and longevity-promoting effects in experimental research.

Key Points:

  • Mechanism of Action: Believed to activate telomerase, helping maintain telomere length, and modulate cellular senescence.

  • Endocrine Effects: May influence pineal gland function, melatonin production, and circadian rhythm regulation.

  • Research Applications: Anti-aging studies, cellular senescence research, oxidative stress models, and experimental endocrine modulation.

  • Structure & Properties: Small, linear, water-soluble tetrapeptide with rapid cellular uptake; sensitive to heat, light, and enzymatic degradation.

  • Status: Investigational; not FDA-approved for clinical use.

Summary

Epithalon acts as a regulatory peptide targeting aging-related pathways, primarily through telomerase activation and pineal gland modulation, making it a widely studied compound in experimental longevity and cellular biology research.

Biochemical
Characteristics

1️⃣ Peptide Structure

  • Type: Synthetic tetrapeptide

  • Amino Acid Sequence: Ala-Glu-Asp-Gly (A-E-D-G)

  • Length: 4 amino acids

  • Molecular Weight: ~302 Da

  • Structure: Linear, small, and water-soluble

2️⃣ Physicochemical Properties

  • Solubility: Highly soluble in water; forms clear solutions

  • Charge: Amphipathic, with acidic residues (Glu, Asp) facilitating solubility

  • pI (Isoelectric Point): Slightly acidic

  • Stability: Sensitive to heat, light, and enzymatic degradation

  • Lyophilized Form: Stable when refrigerated at 2–8 °C

3️⃣ Functional Biochemistry

  • Telomerase Activation: Stimulates telomerase activity in cells to support telomere maintenance

  • Cell Cycle Modulation: May reduce cellular senescence and regulate apoptosis

  • Pineal Gland Effects: Influences melatonin synthesis and potentially circadian rhythm

  • Neuroendocrine Modulation: Indirectly impacts hormonal and oxidative stress pathways

4️⃣ Molecular Behavior

  • Small size enables rapid diffusion and cellular uptake

  • Linear configuration allows interaction with intracellular targets

  • Water-soluble and amphipathic, suitable for research applications in solution

5️⃣ Summary

Epithalon is a small, linear, water-soluble tetrapeptide with biological activity related to telomerase activation, cellular senescence regulation, and pineal gland modulation. Its stability is highly dependent on proper storage and handling, making it primarily suitable for experimental research on aging, longevity, and endocrine regulation.

Research Applications

1️⃣ Anti-Aging and Longevity Studies

  • Investigated for its ability to activate telomerase and maintain telomere length

  • Studied in cellular aging models to delay senescence

  • Used in animal studies to explore lifespan extension and tissue rejuvenation

2️⃣ Cellular Senescence and DNA Repair

  • Explored for reducing cellular markers of senescence

  • May enhance DNA repair mechanisms and genomic stability

  • Useful in research on oxidative stress and age-related cellular damage

3️⃣ Endocrine and Pineal Gland Research

  • Examined for effects on pineal gland function

  • May regulate melatonin production and circadian rhythms

  • Investigated in hormonal modulation studies and experimental chronobiology

4️⃣ Neuroendocrine and Systemic Effects

  • Potential indirect modulation of growth hormone (GH) and other hormonal pathways

  • Studied for effects on stress response and oxidative balance

  • Explored in experimental models for organ function and regeneration

5️⃣ Experimental and Translational Models

  • In vitro studies: Telomerase activity, cell proliferation, senescence

  • In vivo studies: Lifespan, tissue regeneration, endocrine modulation

  • Comparative peptide studies: With DSIP, CJC-1295, and other regulatory peptides

Important Notes

  • Investigational use only; not FDA-approved for clinical therapy

  • Most studies are preclinical or limited clinical trials

  • Effects on humans are not fully established

Summary

Epithalon is primarily used in research to study anti-aging mechanisms, telomerase activation, cellular senescence, pineal gland function, and endocrine modulation. Its small, water-soluble tetrapeptide structure allows for experimental investigation in cellular and animal models of longevity and neuroendocrine regulation.

Chemical Properties
COA /HPLC / MS
3rd Party Testing

Tested by Freedom Diagnostics @ Freedom Diagnostics Testing – Reliable. Accountable. Accessible.

Storage

1️⃣ Lyophilized (Powder) Form

  • Temperature: Store refrigerated at 2–8 °C (36–46 °F)

  • Light Protection: Keep protected from direct light

  • Moisture Protection: Store in the original sealed vial

  • Freezing: Can be stored at −20 °C for long-term preservation

  • Shelf Life: Typically 12–24 months when stored properly

2️⃣ Reconstituted Solution

  • Diluent: Sterile water or bacteriostatic water

  • Temperature: Refrigerate at 2–8 °C

  • Use Period: Typically recommended within 7–14 days

  • Handling: Gently swirl to mix; avoid vigorous shaking

  • Do NOT freeze after reconstitution

3️⃣ General Precautions

  • Inspect solution before use: should be clear and colorless

  • Discard if cloudy, discolored, or containing particulates

  • Use sterile technique for reconstitution and handling

  • Protect from heat, light, and mechanical agitation

✅ Summary

Epithalon is most stable as a lyophilized powder stored refrigerated or frozen. Once reconstituted, it should be kept cold, protected from light, and used promptly to maintain biological activity for research applications.

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