For research use only. Not for human consumption.
CJC-1295 (NO DAC) is a short-acting synthetic peptide analog of growth hormone–releasing hormone (GHRH) that stimulates pulsatile growth hormone release for research purposes. It is used to study GH regulation, IGF‑1 production, and metabolic effects, without the prolonged activity of the DAC version.
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$50.00
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4 in stock
CJC-1295 (NO DAC) is a synthetic, short-acting peptide analog of growth hormone–releasing hormone (GHRH) designed to stimulate natural, pulsatile growth hormone (GH) secretion. Unlike the DAC (Drug Affinity Complex) version, it has a short half-life, resulting in brief, physiologically relevant GH pulses rather than prolonged hormone exposure.
Type: Synthetic GHRH analog (30 amino acids)
Action: Binds to GHRH receptors in the anterior pituitary, triggering GH release
Duration: Short-acting; half-life of a few hours
Effect: Increases GH and IGF-1 levels, influencing metabolism, fat loss, lean muscle growth, and tissue repair
Use: Primarily research and experimental applications; not approved for clinical therapy
Studying growth hormone pulsatility and feedback mechanisms
Investigating body composition changes and metabolic effects
Evaluating exercise recovery and tissue repair in experimental models
Summary:
CJC-1295 (NO DAC) is a short-acting, research-use peptide that mimics natural GHRH activity, producing acute, pulsatile GH release to study hormonal regulation, metabolism, and growth-related processes.
Type: Synthetic peptide analog of growth hormone–releasing hormone (GHRH)
Length: 30 amino acids
Modification: Chemically stabilized at key sites to resist enzymatic degradation, but short-acting (unlike the DAC version)
Linear Structure: Does not form complex tertiary structures; largely maintains an α-helical conformation critical for receptor binding
Amphipathic: Contains both hydrophilic and hydrophobic residues for solubility and receptor interaction
Receptor Binding Domain: Designed to bind GHRH receptors in the anterior pituitary efficiently
Stability Enhancements: Substitutions at vulnerable peptide bonds increase resistance to proteases without extending half-life
Formulation: Lyophilized powder for reconstitution
Solubility: Water-soluble for injection
Storage Stability: Stable when refrigerated (2–8 °C), sensitive to heat and strong agitation
Half-Life: Short, typically 1–2 hours, allowing pulsatile GH release
GH Release: Stimulates pituitary somatotrophs to secrete growth hormone in pulses
IGF-1 Modulation: GH release indirectly increases circulating insulin-like growth factor 1 (IGF-1)
Metabolic Impact: Supports lean body mass increase, fat metabolism, and tissue repair
Receptor Signaling: Activates intracellular cAMP and related pathways in GH-producing cells
CJC-1295 (NO DAC) is a synthetic, short-acting linear peptide with α-helical regions and receptor-specific binding sites, chemically stabilized to resist enzymatic breakdown. Its biochemical design enables pulsatile GH release, IGF-1 induction, and metabolic modulation in research studies.
Studying GH Pulsatility: Used to mimic natural pulsatile growth hormone secretion in research studies.
Pituitary Function Research: Helps investigate GHRH receptor signaling and feedback mechanisms in the anterior pituitary.
IGF-1 Modulation: Indirectly increases insulin-like growth factor 1, useful in studies of growth and metabolism.
Metabolic Research: Evaluates effects on fat metabolism, lean muscle growth, and body composition in experimental models.
Muscle Repair: Assesses GH-mediated improvements in muscle recovery post-injury or exercise.
Tissue Regeneration: Studied for potential effects on collagen synthesis and tissue repair mechanisms.
GHRH Analog Studies: Serves as a model to compare short-acting vs long-acting GH secretagogues.
Drug Development: Provides insight for next-generation GH therapies and pulsatile hormone delivery systems.
Investigational Use: Not FDA-approved; only used in controlled research studies.
Dosing: Frequent injections needed due to short half-life.
Focus: Acute GH responses, rather than long-term sustained GH elevation.
Summary:
CJC-1295 (NO DAC) is primarily used in research to study growth hormone pulsatility, IGF-1 regulation, metabolic effects, and tissue repair, providing short-term GH stimulation without prolonged accumulation.
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Temperature: Store refrigerated at 2–8 °C (36–46 °F).
Light Protection: Keep away from direct light.
Moisture Protection: Keep in the original sealed vial to prevent moisture exposure.
Shelf Life: Typically up to 24 months when stored properly.
Temperature:
Refrigerated: 2–8 °C for short-term use
Room Temperature: Only for very brief periods (generally ≤24 hours)
Handling:
Use sterile syringes
Avoid vigorous shaking; gently swirl to mix
Appearance Check: Solution should be clear to slightly opalescent; discard if cloudy or particulate matter appears
Do not freeze reconstituted peptide; freezing can denature it
Avoid heat and light exposure for both lyophilized and reconstituted forms
Use promptly after reconstitution to maintain activity
✅ Summary:
CJC-1295 (NO DAC) is most stable as a refrigerated lyophilized powder. After reconstitution, it should be used immediately or stored refrigerated for a very short period to preserve potency.
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